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In contrast, the lid domain with P-loop and A-loop enclose the active site in the closed form (3KAL) and partially in the Cp1B structure

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In addition, the nanoscale activator based on Mn-quercetin coordination synthesized by mixing manganese tetrachloride tetrahydrate (MnCl 2 4H 2 O) with an ethanol solution of quercetin, releases manganese ions that promote the generation of ROS, and enhances photothermal-induced DNA damage when combined with quercetin-induced apoptosis and further promotes the release of cytoplasmic DNA thereby activating the cGAS-STING pathway, enhancing immune activation and effectively inhibiting tumor growth (234)

Ponzone R, Biglia N, Jacomuzzi ME, Mariani L, Dominguez A, Sismondi P